Genomic Survey of SARS-CoV-2 Vaccine Breakthrough Infections in Healthcare Workers from Kerala, India

Beena Philomina J,Bani Jolly, Neethu John,Rahul C Bhoyar,Nisha Majeed,Vigneshwar Senthivel, Fairoz Cp,Mercy Rophina,Bindhu Vasudevan,Mohamed Imran,Prasanth Viswanathan,V R Arvinden, Anoop Joseph,Mohit Kumar Divakar, Priyanka R Nair,Afra Shamnath,P Jayesh Kumar,Abhinav Jain, P Geetha,Anjali Bajaj,Samatha Mathew,Vishu Gupta,Srashti Jyoti Agrawal,Vinod Scaria,Sridhar Sivasubbu,Chandni Radhakrishnan

Journal of infection/The Journal of infection（2021）

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摘要

We describe genomic analysis of SARS-CoV-2 isolates from breakthrough infections in six healthcare workers following vaccination with AZD1222/Covishield. Four patients were infected by the variant of concern B.1.1.7 while other isolates possessed E484K and S477N mutations in spike protein associated with immune escape.

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