C(sp³)-H Bond Acylation with N-Acyl Imides under Photoredox/Nickel Dual Catalysis

A novel Ni/photoredox-catalyzed acylation of aliphatic substrates, including simple alkanes and dialkyl ethers, has been developed. The method combines C-N bond activation of amides with a radical relay mechanism involving hydrogen-atom transfer. The protocol is operationally simple, employs bench-stableN-acyl imides as acyl-transfer reagents, and permits facile access to alkyl ketones under very mild conditions.