C(sp3)-H Bond Acylation with N-Acyl Imides under Photoredox/Nickel Dual Catalysis
Synlett(2021)
Abstract
A novel Ni/photoredox-catalyzed acylation of aliphatic substrates, including simple alkanes and dialkyl ethers, has been developed. The method combines C-N bond activation of amides with a radical relay mechanism involving hydrogen-atom transfer. The protocol is operationally simple, employs bench-stableN-acyl imides as acyl-transfer reagents, and permits facile access to alkyl ketones under very mild conditions.
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Key words
nickel catalysis,photocatalysis,acylation,radical relay,C-N bond activation,ketones
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