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Isoform-dependent APOE secretion modulates neuroinflammation

Philip Hasel,Shane A. Liddelow

NATURE REVIEWS NEUROLOGY（2021）

Cited 12|Views4
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Abstract
polipoprotein E (APOE) is the most abundant apolipoprotein in the brain, where it is primarily expressed and secreted by astrocytes and microglia. APOE seems to exert immunomodulatory effects in an isoform-dependent way, and a new study indicates that the APOE isoform dictates the glycosylation state and secretion of this apolipoprotein.
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Key words
Alzheimer's disease,Neurodegenerative diseases,Neuroimmunology,Medicine/Public Health,general,Neurology
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