Hydroazulene Diterpenes From A Dictyota Brown Alga And Their Antioxidant And Neuroprotective Effects Against Cerebral Ischemia-Reperfusion Injury
JOURNAL OF NATURAL PRODUCTS(2021)
摘要
Five new diterpenes, including four new hydroazulenes, (8R,11R)-8, 11- diacetoxypachydictyol A (1), (8R*,11R*) -6-O-acety1-8- acetoxy-11-hydroxypachydictyol A (2), (8R*,11S*)-8-acetoxy-11-hydroxypachydictyol A (3), and (8R*,11S*)-6-O-acety1-8,11-dihydroxypachydictyol A (4), and a secohydroazulene derivative, named 7Z-7,8-seco-7,11-didehydro-8-acetoxypachydictyol A (5), were isolated from a South China Sea collection of a Dictyota sp. nov. brown alga, together with five known analogues (6-10). Structure elucidation was achieved by extensive spectroscopic analysis and comparison with reported data. All compounds showed potent antioxidant effects against H2O2-induced oxidative damage in neuron-like PC12 cells at a low concentration of 2 mu M. The antioxidant property of dictyol C (9) was associated with activation of the Nrf2/ARE signaling pathway; it also showed neuroprotective effects against cerebral ischemia-reperfusion injury (CIRI) in a rat model of transient middle cerebral artery occlusion. As such, hydroazulene diterpenes could serve as lead structures for the development of novel neuroprotective agents against CIRI.
更多查看译文
关键词
hydroazulene diterpenes,antioxidant,neuroprotective effects,brown alga,ischemia-reperfusion
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要