Changes in Smad1/5/9 expression and phosphorylation in astrocytes of the rat hippocampus after transient global cerebral ischemia

Takayuki Nakajima,Yuji Kunieda,Yusuke Takahashi,Yuki Tanaka,Tomohiro Kondo,Shigeo Takenaka

Journal of Chemical Neuroanatomy（2021）

Cited 3|Views6

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Abstract

•Smad1/5/9 immunoreactivity increased in CA1 astrocytes after ischemia.•Phospho-Smad1/5/9-immunopositive cell number transiently increased after ischemia.•Immunoreactivity for phospho-Smad1/5/9 was found in GFAP-immunopositive astrocytes.•The expression level of TGF-β1 mRNA increased in the hippocampus after ischemia.•SB525334 prevented ischemia-induced increase in phospho-Smad1/5/9-positive cells.

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Key words

Global cerebral ischemia,Smad 1/5/9,Hippocampus,TGF-β,Rat

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