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In silico技术对化妆品成分的经皮暴露评估

JOURNAL OF HEALTH TOXICOLOGY(2009)

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Abstract
In silico的技术核心为(定量)结构活性关系,即(Q)SAR[(Quantitative)structure activity relationship]技术,原理基于分析研究分子或原子的基本结构特征及其理化性质以(定量)揭示化合物毒性及生物学活性[1-2].近年来,各国纷纷开展了毒理学领域的动物替代技术研究,发达国家相关法律法规的推行,更是大大地推动了动物替代方法研究的进步.
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