乳腺导管内癌与浸润性导管癌分子表型的关系
Chinese Journal of Clinical and Experimental Pathology(2015)
Abstract
目的:探讨乳腺导管内癌( ductal carcinoma in situ, DCIS)与浸润性导管癌( invasive ductal carcinoma, IDC)分子表型之间的关系。方法采用免疫组化法检测ER、PR、HER-2及CK5在165例乳腺癌组织中的表达,每例均包含DCIS和IDC病变。结果165例乳腺癌组织中,IDC与DCIS中ER、PR、HER-2及CK5表达呈正相关,IDC中基底细胞样型18例(10.9%),HER-2过表达型19例(11.5%),腺腔A型102例(61.8%),腺腔B型20例(12.1%),空白型6例(3.6%);DCIS中基底细胞样型19例(11.5%),HER-2过表达型20例(12.1%),腺腔A型104例(63%),腺腔B型17例(10.3%),空白型5例(3.0%)。IDC与DCIS表达一致者157例(95.2%),不一致者8例(4.8%),其中3例腺腔A型DCIS分别发展成为1例HER-2过表达型和2例空白型IDC,3例HER-2过表达型DCIS发展成为腺腔B型IDC,1例空白型DCIS发展成为1例腺腔A型,1例基底细胞样型发展成为HER-2过表达型IDC。结论绝大多数DCIS进展为具有相同分子表型的IDC,少数可转化为其他类型。
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Key words
breast neoplasms,ductal carcinoma in situ,invasive ductal carcinoma,immunophenotyping
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