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蛋白二硫键异构酶调控组织因子介导的凝血酶生成

Feng-wu CHEN,Yi LU,Jun-song ZHOU

Chinese Journal of Thrombosis and Hemostasis（2016）

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Abstract
目的 研究蛋白二硫键异构酶(protein disulfide isomerase,PDI)在血栓形成中的机制.方法 应用重组PDI蛋白和PDI基因敲除小鼠通过凝血酶生成实验(thrombin generation asaay,TGA)探讨PDI对组织因子促凝活性的调控作用.结果 组织因子抗体(4501)几乎完全抑制单核细胞介导的凝血酶产生(P＜0.001),表明该凝血反应依赖于组织因子;重组PDI蛋白(rPDI ss-ss)促进凝血酶的产生(P＜0.01);相比野生型单个核细胞,PDI敲除的单个核细胞促凝活性明显降低(P＜0.05).结论 PDI对于组织因子介导的凝血酶生成具有重要的调控作用.
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Key words
Protein disulfide isomerase,Tissue factor,Thrombin generation
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