类风湿关节炎患者血清中诱骗受体3的检测及临床意义
Chinese Journal of Rheumatology(2013)
Abstract
目的 检测类风湿关节炎(RA)患者血清中诱骗受体3(DcR3)的水平,分析其在RA中的临床意义.方法 收集RA患者血清180例,健康对照者100名,骨关节炎患者29例,系统性红斑狼疮(SLE)患者60例,干燥综合征(SS)患者30例,采用双抗体夹心酶联免疫吸附试验(ELISA)测定血清中的DcR3水平,并分析血清DcR3水平与RA各临床和实验室指标的相关性,计量资料的比较采用独立样本t检验,计数资料比较采用x2检验,相关性分析采用Spearman相关分析.结果 RA患者血清DcR3水平为(202±261) ng/ml,显著高于健康对照组[(32±31) ng/ml,t=5.33,P<0.01],OA患者[(90±33) ng/ml,t=1.998,P<0.01],SLE患者[(41±56) ng/ml,t=3.19,P<0.01]和SS患者[(25±31) ng/ml,t=2.50,P<0.01];根据健康人和其他疾病对照确定DcR3的诊断浓度为45.86 ng/ml,敏感性为0.991,特异性为0.765.血清DcR3水平与类风湿因子(RF) IgM、RF-IgG、抗环瓜氨酸肽(CCP)抗体呈正相关(r值分别为0.58,0.54,0.411,P<0.05),与补体C3 (C3)呈负相关(r=-0.226,P<0.05).结论 DcR3在RA患者血清中表达增高,并与疾病免疫指标密切相关(包括RF-IgM、RF-IgG、C3和抗CCP抗体),可能是RA预后不良因素之一.
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Key words
Arthritis,rheumatoid,Receptors,tumor necrosis factor,member 6b,Rheumatoid factor,Anti-cyclic citrullinated peptide antibodies
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