大汗腺肿瘤凝集素亲和组化研究
CHINESE JOURNAL OF DERMATOVENEROLOGY OF INTEGRATED TRADITIONAL AND WESTERN MEDICINE(2005)
Abstract
目的探讨皮肤大汗腺肿瘤细胞表面凝集素受体的变化规律及意义.方法用17种生物素化凝集素检测了21例大汗腺良恶性肿瘤细胞表面凝集素受体的表达情况.结果大汗腺恶性肿瘤细胞表面WGA、ECL、STL、PNA、RCA-Ⅰ、RCA-Ⅱ阳性率较低,与良性肿瘤相比差异有显著性,DBA、BSL-Ⅰ、UEA-Ⅰ、SBA在部分Paget's病细胞阳性.生乳头汗管囊腺瘤、生乳头汗腺腺瘤、大汗腺混合瘤在PNA、RCA-Ⅰ、ECL阳性着染相似.结论大汗腺良恶性肿瘤细胞膜表面凝集素受体发生了有意义的变化,某些凝集素受体的变化可能有助于大汗腺肿瘤的诊断和鉴别诊断.
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