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AKR1C3在放疗食管癌患者病理标本检测中的意义

Jing ZHAO,Wei XIONG,De-min ZHOU,Xian-shu GAO,Jun REN

Military Medical Sciences（2017）

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Abstract
目的 对单纯放疗食管癌患者病理标本进行检测,评估醛固酮类还原酶家族1成员C3(AKR1C3)表达与放疗效果的关系.方法 回顾性分析28例行单纯放疗的局部晚期食管癌患者的临床资料,通过免疫组化检测食管癌患者中AKR1C3的表达情况.结果 AKR1C3在不同分化程度的食管癌患者中表达程度不同,其表达水平与放疗短期疗效呈负相关(P=0.031,95%可信区间 0.151～0.914).结论 AKR1C3有可能成为食管癌放疗疗效判定的敏感性指标.
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Key words
esophageal neoplasms,radiotherapy,AKR1C3
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