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替加环素致重度肝损伤1例

Gang-ying CHENG,Biao CHENG,Qing ZHOU,Jue LIU,Yi WANG,Ai-ping DENG

Chinese Journal of Drug Application and Monitoring（2018）

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Abstract
1例61岁女性患者,因腹痛3 d入院,临床诊断为急性胃穿孔、感染性休克,在急诊全麻气管插管下行剖腹探查+胃穿孔修补术,术后给予抗休克、补液、抗感染治疗,治疗期间患者总胆红素进行性上升,最高升至158.9μmol?L-1,腹部CT提示胆汁淤积.医生排除疾病相关因素,临床药师考虑替加环素引起药物性肝损害可能性较大,建议停用替加环素.停药后患者总胆红素逐渐下降,停药后第43日患者肝功能指标完全恢复正常,腹部CT提示胆汁淤积消失,患者好转出院.
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