枸地氯雷他定片致肝损伤及皮疹
Adverse Drug Reactions Journal(2020)
Abstract
1例32岁男性患者因过敏性鼻炎口服枸地氯雷他定片8.8 mg、1次/d。用药第6天腹部出现零星红色皮疹,未在意;用药第7天皮疹增多,伴瘙痒,尿液呈深棕色,双手、巩膜出现黄染。实验室检查示丙氨酸转氨酶(ALT)323 U/L,天冬氨酸转氨酶(AST)186 U/L,γ-谷氨酰转移酶(γ-GT)309 U/L,总胆红素(TBil)63.9 μmol/L,直接胆红素(DBil)33.6 μmol/L,诊断:药物性肝损伤,过敏性皮炎。考虑为枸地氯雷他定所致,停用该药,给予保肝治疗及糠酸莫米松乳膏外涂。停用枸地氯雷他定第2天,患者尿液颜色变浅;第4天皮疹颜色变浅,尿液颜色恢复正常,无新发皮疹;第9天皮疹基本消退,肝功能检查示ALT 84 U/L,AST 29 U/L,γ-GT 187 U/L,TBil 19.5 μmol/L,DBil 8.0 μmol/L。2周后复查:ALT 54 U/L,其他检查结果均在参考值范围内。
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Key words
Loratadine,Chemical and drug induced liver injury,Drug eruptions
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