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联合胃蛋白酶原、胃泌素、粪便Hp抗原检测对萎缩性胃炎和胃癌的诊断价值

Hui-mei CAI,Hui LIN,Xi-long OU,Yu-dian HUANG,Yue-hua FANG,Juan SUN,Wen-yu CAO,Jian-ying FU

Journal of Southeast University(Medical Science Edition)（2018）

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Abstract
目的:探索胃蛋白酶原(PG)、胃泌素及粪便幽门螺杆菌抗原(HpSA)在萎缩性胃炎及胃癌中的诊断价值.方法:使用酶联免疫吸附法检测萎缩性胃炎及胃癌患者血清中PGⅠ、PGⅡ及胃泌素-17( G-17)水平,并计算PGR(PGⅠ/PGⅡ)值;采用受试者工作特征曲线( ROC曲线)分析各指标的诊断价值;使用免疫胶体金法检测HpSA的阳性率.结果:萎缩性胃炎组和胃癌组较对照组的PGⅠ水平和PGR值下降,G-17水平上升,HpSA阳性率增高,差异均具有统计学意义. PGⅠ、PGR及G-17具有诊断萎缩性胃炎和胃癌的价值.联合PGⅠ、PGR、G-17和HpSA检测对萎缩性胃炎和胃癌的诊断评估效果最佳.结论:联合检测PG、G-17和HpSA可有效诊断萎缩性胃炎和胃癌.
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Key words
pepsinogen,gastrin,Helicobacter pylori stool antigen,diagnosis,gastric cancer,atrophic gastritis
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