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δ-阿片受体在中枢神经系统中的作用

Si Teng,Tao Chen,Yidong Deng,Yanhui Liu,Shan Zhang,Jiali Su,Benchi Cai

Journal of Chinese Physician（2018）

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Abstract
δ-阿片受体(DOR)是一类具有7个跨膜区域的抑制性G蛋白偶联受体,是一种经典镇痛药物,广泛存在于中枢系统和外周系统中.研究表明,阿片受体除了疼痛调制作用,还通过基因或细胞因子广泛参与各种生理以及病理活动.本文综述δ-阿片受体在缺血性脑损伤、镇痛、抗焦虑抑郁、学习记忆以及帕金森病中的作用及可能机制.
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Key words
receptor,central nervous system
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