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Ⅱ型Crigler-Najjar综合征合并慢性乙型肝炎1例及文献复习

何登明,闫成玉,刘文清

Practical Journal of Medicine & Pharmacy（2020）

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Abstract
遗传性高非结合胆红素血症主要包括Gilbert综合征(Gilbert syndrome,GS)和Crigler-Najjar综合征(Crigler-Najjar syndrome,CNS),其发病机制在于尿苷二磷酸葡萄糖醛酸转移酶1A1(UDP-glucuronosyl transferase 1A1,UGT1A1)基因多态性[1-3].我国的慢性HBV感染主要来自母婴垂直传播,进入免疫清除期后出现肝炎活动,表现为肝功能异常[4].
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