Enhanced nuclear-spin hyperpolarization of amino acids and proteins via reductive radical quenchers
Journal of Magnetic Resonance(2021)
摘要
•Vitamin C (VC) and 2-mercaptoethylamine (MEA) prevent photodamage in LC-photo-CIDNP.•Only low-micromolar concentrations of the VC and MEA additives are necessary.•VC or MEA enhance LC-photo-CIDNP sensitivity by ≥2-fold in long expts (256 scans)•VC acts mainly on the NMR molecule of interest (aromatic amino acids, proteins)•We propose that VC acts primarily by reducing transient Trp/Tyr radical populations.
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关键词
Photo-CIDNP,Liquid-state NMR,Hyperpolarization,Sensitivity enhancement,LC-photo-CIDNP,Vitamin C,Reductive radical quencher,2-Mercaptoethylamine
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