Abstract 142: Combined Therapy with Polyethylene Glycol-20k and MCC950 Preserves Post-resuscitation Myocardial Mitochondrial Function in a Rat Model of Cardiac Arrest and Cardiopulmonary Resuscitation

Lian Liang,Guozhen Zhang,Hui Li,Cheng Cheng,Tao Jin, Chengli Su,Yan Xiao,Jennifer Bradley,Ria Fyffe-Freil,Mary Ann A Peberdy,Joseph P Ornato,Martin Mangino,Wanchun Tang

Circulation（2020）

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摘要

Introduction: Mitochondrial dysfunction from global ischemic-reperfusion (I/R) injury is a major contributor to post-resuscitation myocardial dysfunction. Polyethylene Glycol-20k (PEG-20k) shortens...

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cardiac arrest,mitochondrial,post-resuscitation

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