Multifunctional Fe3O4@SiO2-CDs magnetic fluorescent nanoparticles as effective carrier of gambogic acid for inhibiting VX2 tumor cells
Journal of Molecular Liquids(2021)
摘要
This paper reports a dual-functional platform that can be used for synergistic therapy, including drug release and magnetic targeting. The platform is realized through an amide reaction between high-fluorescence carbon quantum dots (CD) prepared by microwave method and amino-functional Fe3O4@SiO2 with high saturation magnetic strength and a core-shell structure to obtain multifunctional magnetic fluorescent nanocomposite particles Fe3O4@SiO2-CDs. The structure, drug release behavior, cytotoxicity, fluorescence and distribution in vivo of Fe3O4@SiO2-CDs nanoparticles were studied. The results show that the Fe3O4@SiO2-CDs with a dynamic diameter of about 155.0 nm and a magnetic saturation intensity of 31.2 emu/g has a higher loading of gambogic acid (GA), and is more conducive to drug release in an environment of pH = 5.7. In addition, Fe3O4@SiO2-CDs has low cytotoxicity and can enter VX2 cells. However, GA-loaded Fe3O4@SiO2-CDs has an inhibitory effect on VX2 cells, and the cell survival rate is less than 20% at a concentration of 100 μg/mL. Magnetic targeting experiments show that bifunctional magnetic nanoparticles have an outstanding magnetic targeting effect on tumors.
更多查看译文
关键词
Magnetic nanoparticles,Fluorescent carbon quantum dots,Magnetic targeting,Tumor therapy,Drug sustained release
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要