Corticosteroid-resistant Sweet Syndrome in the Setting of Acute Myeloid Leukemia with Monosomy 7 and 5q Deletion

Sweet syndrome (SS), otherwise known as acute neutrophilic febrile dermatosis, typically manifests in the fourth or fifth decade of life and is characterized by fever and a cutaneous eruption of painful erythematous and edematous papules, plaques, or nodules.1,2 Histopathologically, the cutaneous manifestation is characterized by a predominant neutrophilic dermal infiltrate with associated papillary dermal edema.1 Three subtypes of SS have been recognized in the literature: classic, malignancy associated and drug induced.