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CXCL5/CXCR2生物轴在胰腺癌中的研究进展

Journal of International Oncology(2017)

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Abstract
胰腺癌的增殖、进展、转移是一个多因素参与的过程.其中,CXC类趋化因子配体5(CXCL5)能够识别并结合CXC类趋化因子受体2(CXCR2),通过细胞自分泌或旁分泌等途径激活或调节信号通路的表达.CXCL5/CXCR2生物轴能够在胰腺癌细胞的增殖、黏附、侵袭、转移和预后中发挥作用,并且与胰腺癌血管及淋巴管生成等相关.直接或间接调控CXCL5/CXCR2在胰腺癌中的表达,有望成为靶向治疗胰腺癌的有效手段.
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Key words
Pancreatic neoplasms,Chemokine CXCL5,Receptor,interleukin-8B
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