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Synthesis of 3-Morpholin-4-yl-1-(4-nitrophenyl)-5,6-dihydro-1h-pyridin-2-one

Advances in engineering research/Advances in Engineering Research(2016)

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摘要
3-Morpholin-4-yl-1-(4-nitrophenyl)-5,6-dihydro-1H-pyridin-2-one (1) is an important intermediate for the synthesis of many biologically active compounds. It was synthesized from cyclopentanone oxime (7) and 1-fluoro-4-nitrobenzene through three steps including rearrangement. Reaction, condensation and nucleophilic substitution reaction. The structure of the target compound 1 was confirmed by H-1 NMR and MS spectrum.
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关键词
3-Morpholin-4-y l-1-( 4-nitropheny l)-5,6-dihydro-1 H - pyridin-2-one,Synthesis,Cyclopentanone oxime
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