The Relationship Between HLA Disparity and Clinical Outcomes in Peripheral Blood T Cell Replete Haploidentical Hematopoietic Cell Transplantation

Introduction: For patients undergoing mismatched unrelated donor hematopoietic cell transplant (HCT), increased HLA mismatch has been associated with inferior survival.Whilehaploidentical HCT (haplo-HCT) with high dose post-transplantation cyclophosphamide (PTCy) offers a viable alternative for patients who do not have a matched sibling donor or matched unrelated donor, limited data are available regarding the impact of HLA disparity on outcomes. Specifically, no analysis to date has examined the role of mismatch degree in the graft-versus-host (GvH) and host-versus-graft (HvG) directions in a large, heterogenous cohort of patients undergoing peripheral blood T cell replete haplo-HCT. Thus, the purpose of our study was to examine the relationship between HLA disparity and clinical outcomes in patients receiving a peripheral blood T cell replete haplo-HCT.