A Voltage-Responsive Synthetic Cl--Channel Regulated by pH
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION(2020)
摘要
Transmembrane protein channels are an important inspiration for the design of artificial ion channels. Their dipolar structure helps overcome the high energy barrier to selectively translocate water and ions sharing one pathway, across the cell membrane. Herein, we report that the amino-imidazole (Imu) amphiphiles self-assemble via multiple H-bonding to form stable artificial Cl--channels within lipid bilayers. The alignment of water/Cl(-)wires influences the conduction of ions, envisioned to diffuse along the hydrophilic pathways; at acidic pH, Cl-/H(+)symport conducts along a partly protonated channel, while at basic pH, higher Cl-/OH(-)antiport translocate through a neutral channel configuration, which can be greatly activated by applying strong electric field. This voltage/pH regulated channel system represents an unexplored alternative for ion-pumping along artificial ion-channels, parallel to that of biology.
更多查看译文
关键词
biomimetics,H-bonding,ion channels,self-assembly,water,Cl(-)wires
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要