Differential toll like receptor expression in cystic fibrosis patients' airways during rhinovirus infection

Carolina Scagnolari,Camilla Bitossi,Federica Frasca,Agnese Viscido,Gabriele Brazzini,Maria Trancassini,Valeria Pietropaolo,Fabio Midulla,Giuseppe Cimino,Paolo Palange,Alessandra Pierangeli,Guido Antonelli

Journal of Infection（2020）

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摘要

•HRV is frequently found in the respiratory tract of CF patients.•HRV can be associated to pulmonary exacerbations in CF patients.•HRV load did not vary according to CF patients age.•HRV infection affects the expression of TLRs in CF patients.•TLR2 and TLR4 levels are increased in HRV positive CF patients.•TLRs expression changed according to the specific HRV-bacteria species interaction.

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关键词

Cystic fibrosis,Rhinovirus,Toll like receptors,Viral load,Virus-bacteria interaction

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