Health Related Quality of Life in End-Stage Renal Disease Patients

Background: The purpose of this study is to assess the psychosocial reality of patients undergoing renal replacement therapy (RRT) with peritoneal dialysis (PD) in a level III University Hospital. This study also evaluated the prevalence of anxiety and depression in this cohort of subjects. Methods: Observational, prospective and cross-sectional study conducted, from January to December 2018, on patients undergoing RRT with PD. Health related quality of life (HRQOL) was evaluated by means two different methods: A visual analogue scale (VAS) score and the Medical Outcomes Survey Short Form-36 (SF-36) questionnaire. Utility measurements were evaluated by means the EuroQol 5D (EQ-5D), the Health Utilities Index Mark III (HUI3) and the SF-6 Dimension (SF-6D). The State-Trait-Anger-eXpression-Inventory (STAXI) and the Hospital Anxiety and Depression Scale (HADS) were used as clinical scales. Results: Fifty-eight patients were included in the analysis. Mean VAS score was 66.8 (16.8). Physical component of SF-36 exhibited a mean value of 40.9 (7.5), while the mental component of the SF-36 reached a mean value of 47.6 (10.2). Mean utility score observed with SF-6D [0.65 (0.20)] was significantly lower than that obtained with the EQ-5D [0.75 (0.16), p=0.0025] or the HUI3 [0.82 (0.23), p=0.0001], respectively. According to the HADS scores, a 6.8% of patients can be categorized within the category of clinical anxiety and 13.6% in the category of clinical depression. Conclusions: The results of this study suggested that end-stage renal disease and RRT impact on the HRQOL, but not in all the dimensions at the same level.