Ileocecal Valve Removal Reverses the Constipating Effects of Loperamide in Rats.

Anastasia Mentessidou,Anastasia Livani,George Chrousos,Petros Mirilas

Journal of Surgical Research（2020）

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摘要

ICVR led to an effective, similar to TC, reversal of the constipating effects of loperamide and, unlike TC, was not associated with diarrhea. Our findings support the idea that ICVR might be beneficial in disorders with inhibited proximal colon transit resulting from fecal dehydration and hypoperistalsis, such as refractory cystic fibrosis-related intestinal obstruction. Potential clinical implications merit further study.

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关键词

Cystic fibrosis,Distal intestinal obstruction syndrome,Ileocecal valve removal,Intestinal transit,Loperamide-induced constipation

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