Acute and Chronic Toxicity of Deltamethrin, Permethrin, and Dihaloacetylated Heterocyclic Pyrethroids in Mice

BACKGROUND Pyrethroids, a class of insecticides, acted on the nervous system of insects. Frequent consumption of foods with pyrethroid residues increased the risk of developmental and neurological diseases in human. Assessing the toxicity of novel synthetic pyrethroids to mammals was also critical to the development of agrochemicals. RESULTS Using mice as models, the acute and chronic toxicity of deltamethrin, permethrin, dihaloacetylated pyrethroids to mammals was researched by gavage administration. Acute toxicity assessment displayed that the LD50 of deltamethrin, permethrin and dihaloacetylated heterocyclic pyrethroids DCA-O, DCA-01, DCA-11 tested were greater than 500 mg/kg of weight. And chronic toxicity assessment demonstrated that deltamethrin, permethrin caused epidermal damage near the genitals, while dihaloacetylated heterocyclic pyrethroids DCA-O, DCA-01, DCA-11 showed no relevant symptoms. However, both the acute and chronic toxicity assessment suggested that pyrethroids exposure induced mice loss weight. Additionally, the elevated plus maze (EPM) test showed that pyrethroids caused anxiety-like behaviors and no motor defects in Kunming mice. Beside, during the sucrose preference test (SPT), 60-day pyrethroids exposure increased excitatory behaviors in mice. And the neurochemical studies displayed that pyrethroids exposure increased the total amount of glutamate (Gln), glutamine (Glu) and γ-aminobutyric acid (GABA) in the mice's blood. CONCLUSION Pyrethroids exposure induced weight loss in mice, although the acute oral toxicity of deltamethrin, permethrin and dihaloacetylated heterocyclic pyrethroid DCA-O, DCA-01, DCA-11 was low. And regarding chronic toxicity, deltamethrin, permethrin and dihaloacetylated heterocyclic pyrethroid DCA-O, DCA-01, DCA-11 induced anxiety-like behaviors, excitatory behaviors, Gln-Glu-GABA circulatory dysfunction in blood. Particularly, deltamethrin, permethrin also had reproductive toxicity. This article is protected by copyright. All rights reserved.