LC-MS bioanalytical method for simultaneous determination of latanoprost and minoxidil in the skin.
Journal of Pharmaceutical and Biomedical Analysis(2020)
摘要
•Method could simultaneously determine minoxidil and latanoprost in skin layers.•The method demonstrated to be selective, linear, sensitive, and precise.•Recovery experiments achieved high levels of drugs extracted from the skin layers.•Effective bioanalytical method when tested in in vitro skin penetration studies.
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关键词
Bioanalytical method,Latanoprost,Liquid chromatography,Mass spectroscopy,Minoxidil,Skin permeation
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