P136 Determinants of Arterial Stiffness in Children Using Population-indexed Anthropometric and Hemodynamic Parameters

Background Arterial stiffness is a significant cardiovascular risk factor. Carotid-femoral pulse wave velocity (cfPWV) is the standard for measuring arterial stiffness, but indices such as central augmentation index (cAIx) and carotid artery elasticity (cE[p]) also correlate to arterial stiffness. Early-life determinants of arterial stiffening are not well understood. We assessed the relationship between population-indexed anthropometric and hemodynamic parameters, and arterial stiffness in healthy children. Methods 97 healthy children between 2 to 20 years old were recruited. Z -scores for height, BMI, and brachial systolic (bSBP) and diastolic (bDBP) blood pressure were calculated [ 1 , 2 ]. cfPWV and central arterial waveforms were measured using the Sphygmocor XCEL and CvMS devices (AtCor, Sydney) respectively. Carotid artery maximum and minimum diameters were measured by high-resolution ultrasonography. cfPWV, cE[p], and cAIx were calculated. Results In bivariate analysis, cfPWV was associated with age ( b = 0.52, p < 0.01) and bSBP z -score ( b = 0.24, p = 0.03). These associations were independent of sex, height z -score, BMI z -score, and bDBP z -score in a multivariable model ( R 2 = 0.23). cE[p] was significantly associated with age ( b = 0.42, p < 0.01), bSBP z -score ( b = 0.45, p < 0.01), and height z -score ( b = -0.33, p = 0.01), but only bSBP z -score remained statistically significant in the multivariable model ( b = 0.45, p < 0.01; R 2 = 0.20). cAIx was not associated with anthropometric or hemodynamic z -scores. Conclusion cfPWV is associated with age and bSBP z -score, while cE[p] is associated with bSBP z -score only, suggesting a potentially key association between systolic blood pressure and indices of arterial stiffness independent of age and other parameters of growth during healthy early life.