Synergistic interaction between butorphanol and dexmedetomidine in antinociception

Muhammad Zaeem Ahsan,Farhan Ullah Khan,Meng-Jing Zhao,Yong-Xiang Wang

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES（2020）

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摘要

•Butorphanol produces antinociception by targeting MORs, KORs and DORs.•Dexmedetomidine displays antinociception via α2ARs.•Coadministered butorphanol and dexmedetomidine produces synergistic antinociception.•The synergistic antinociception is mediated by activation of MORs, KORs, DORs and α2ARs.•Coadministered butorphanol and dexmedetomidine induces synergistic sedation.

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关键词

Butorphanol,Dexmedetomidine,Synergism,Isobologram,Antinociception,Acute nociceptive pain

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