Clostridioides difficile infections among healthcare workers

•Information regarding C difficile infection cases among HCWs is limited.•Colonization among HCWs range from 0% to 13%.•This is the largest case-series reported so far consisting of 9 HCWs.•Prior antibiotic use (RR 4.5) and PPI (RR 2.0) were significant for CDI development.•Taking care of patients with CDI proved not to be a significant risk factor.