Protective effects of iridoid glycosides on acute colitis via inhibition of the inflammatory response mediated by the STAT3/NF-кB pathway.

•Morroniside and loganin was able to ameliorate intestinal barrier injury and inflammatory reaction in mice models.•The proinflammatory cytokines production was significantly reduced in morroniside and loganin-treated mice.•The possible mechanism of anti-inflammatory response may involve in the blocking of STAT3/NF-κB pathway in vivo.•Morroniside and loganin remarkably suppressed the inflammatory response via the STAT3/NF-кB pathway in vitro.