Cocaine‐associated Atypical Haemolytic Uraemic Syndrome in a Genetically Susceptible Individual
Nephrology(2020)
摘要
Atypical haemolytic uraemic syndrome (aHUS) is a severe, life‐threatening condition that requires early recognition and urgent treatment. In aHUS rare genetic variants in CFH, CFI, CD46, C3 and CFB predispose to complement over activation. This case describes a case of aHUS in which there was a strong temporal association between disease onset and the use of smoked cocaine. The patient was found to have a rare genetic variant in the CFI gene which may have been unmasked by first‐time exposure to cocaine. The patient stabilized and improved with early administration of eculizumab, supporting the notion of an underlying immunological pathogenesis and the importance of early intervention.
更多查看译文
关键词
atypical haemolytic uremic syndrome,cocaine,complement activation,complement inactivating agents,thrombotic microangiopathies
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要