Expression of BAP1 and ATM proteins: Association with AJCC tumor category in uveal melanoma.
Annals of Diagnostic Pathology(2020)
摘要
•BAP1 and ATM proteins trigger DNA damage response (DDR) which leads to DNA repair.•ATM modifies the BAP1for the activation of DNA repair which signifies that there is a connecting link between ATM and BAP1.•Our findings demonstrate the synergistic role of ATM and BAP1 proteins and may have a therapeutic potential in uveal melanoma.
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关键词
Uveal Melanoma,BAP1,ATM,Co-expression,Immunohistochemistry,AJCC tumor category
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