Crystal Structure of the Putative Cyclase IdmH from the Indanomycin Nonribosomal Peptide Synthase/polyketide Synthase.
IUCRJ(2019)
摘要
The crystal structure of IdmH from the biosynthetic gene cluster for indanomycin is presented. NMR data show that this enzyme binds its postulated product, indanomycin, and QM/MM modelling of the reaction strongly supports the view that IdmH catalyses indane-ring formation in indanomycin biosynthesis via a Diels–Alder reaction.
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关键词
polyketide biosynthesis,antibiotics,Steptomyces antibioticus,cycloaddition,crystal structure,protein crystallography,QM/MM reaction modelling,Diels-Alder reaction
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