Disseminated Cutaneous Immunoglobulin M Macroglobulinosis Associated with Cryoglobulinemia and Minimal Residual Disease of Waldenström Macroglobulinemia.

The dermatologic manifestations of Waldenström macroglobulinemia (WM) are typically categorized as disease specific or non–disease specific.1 Non–disease-specific findings are related to hyperviscosity or cryoglobulinemia, including mucosal bleeding, purpura, livedo reticularis, and Raynaud phenomenon. Two rare types of specific skin findings have been identified: cutaneous infiltrates of mature B-cell neoplasms, specifically heavy-chain or malignant immunoproliferative diseases, and deposits of monoclonal immunoglobulin (Ig) M, referred to as cutaneous macroglobulinosis (CM).