Structural Elucidation Of Two New Compounds From Artemisia Ordosica And Their Antioxidative Activity

Two new compounds, namely, arteordosin A (1) and arteordosin B (2), were isolated from the CHCl3 extract of Artemisia ordosica. This is the first report on the structure elucidation of arteordosin A (1) and arteordosin B (2) based on spectroscopic methods including electrospray ionization mass spectrometry, one-dimensional (1D) nuclear magnetic resonance spectroscopy (NMR) and 2D NMR techniques. Antioxidant activities of the compounds were measured for their radical scavenging capacity using 2,2-diphenyl-1-picrylhydrazyl. Compound 1 (IC50 of 1.01 mg mL(-1)) showed antioxidant activity similar to the standard reference ascorbic acid (IC50 of 0.98 mg mL(-1)) and is more active than compound 2 (IC50 of 1.87 mg mL(-1) ). In conclusion, arteordosin A (1) and arteordosin B (2) may be used as potential antihyperlipidemic agent in routine clinical practice.