Screening Of Pcsk9 Gene In Indian Familial Hypercholesterolemia Patients

Background and Aims: Familial Hypercholesterolemia (FH) is an autosomal dominant disease characterized by elevated levels of LDL-cholesterol caused by mutations in low density lipoprotein receptor (LDLR), apolipoprotein B (ApoB) and Proprotein convertase subtilisin/kexin type 9 (PCSK9). Our aim was to identify FH patients and detect mutations in entire PCSK9 gene in Indian population.