Fuzzy Semantic Segmentation of Breast Ultrasound Image with Breast Anatomy Constraints.

Breast cancer is one of the most serious disease affects women's health. Due to low cost, portable, no radiation, and high efficiency, breast ultrasound (BUS) imaging is the most popular approach for diagnosing early breast cancer. However, ultrasound images are low resolution and poor quality, developing accurate detection system is a challenging task. In this paper, we propose a fully automatic segmentation algorithm consisting of two parts: fuzzy fully convolutional network and accurately fine-tuning post-processing based on breast anatomy constraints. In the first part, the image is preprocessed by contrast enhancement, and wavelet features are employed for image augmentation. A fuzzy membership function transforms the augmented BUS images into fuzzy domain. The features from convolutional layers are processed using fuzzy logic as well. The conditional random fields (CRFs) post-process the segmentation result. The location relation among the breast anatomy layers is utilized to improve the performance. The proposed method is applied to the dataset with 325 BUS images, and achieves state-of-art performance compared with that of existing methods with true positive rate 90.33%, false positive rate 9.00%, and intersection over union (IoU) 81.29% on tumor category, and overall intersection over union (mIoU) 80.47% over five categories: fat layer, mammary layer, muscle layer, background, and tumor.