A complex and cryptic intrachromosomal rearrangement generating the FIP1L1_PDGFRA in adult acute myeloid leukemia.
Cancer Genetics(2019)
摘要
•PDGFRA gene rearrangement is reported in myeloid neoplasms with eosinophilia and confers sensitivity to tyrosine kinase inhibitors therapy.•FIP1L1/PDGFRA fusion gene is originated from a new, cryptic and complex intrachromosomal rearrangement of 4q12.•The molecular characterization of the peculiar chromosomal rearrangement and the associated genomic alterations is conducted.
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关键词
Acute myeloid leukemia,Eosinophilia,PDGFRA,FIP1L1
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