Anti-OX40 Antibody Directly Enhances The Function of Tumor-Reactive CD8 + T Cells and Synergizes with PI3Kβ Inhibition in PTEN Loss Melanoma.
Clinical cancer research : an official journal of the American Association for Cancer Research（2019）
摘要
These results highlight a critical role of OX40 activation in potentiating the effector function of tumor-reactive CD8 T cells and suggest further evaluation of OX40 agonist-based combinations in patients with immune-resistant tumors.
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