Modulation of the Wnt pathway through inhibition of CLK2 and DYRK1A by lorecivivint as a novel, potentially disease-modifying approach for knee osteoarthritis treatment.

V Deshmukh, A L O'Green,C Bossard,T Seo,L Lamangan,M Ibanez, A Ghias,C Lai,L Do,S Cho,J Cahiwat,K Chiu,M Pedraza, S Anderson, R Harris,L Dellamary,S Kc,C Barroga,B Melchior,B Tam,S Kennedy,J Tambiah,J Hood,Y Yazici

Osteoarthritis and Cartilage（2019）

引用 102|浏览27

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摘要

Lorecivivint inhibition of CLK2 and DYRK1A suggested a novel mechanism for Wnt pathway inhibition, enhancing chondrogenesis, chondrocyte function, and anti-inflammation. Lorecivivint shows potential to modify structure and improve symptoms of knee OA.

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关键词

Lorecivivint,SM04690,Osteoarthritis,Wnt pathway,CLK2,DYRK1A,Chondrocyte

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