Modulation of the Wnt pathway through inhibition of CLK2 and DYRK1A by lorecivivint as a novel, potentially disease-modifying approach for knee osteoarthritis treatment.
Osteoarthritis and Cartilage(2019)
摘要
Lorecivivint inhibition of CLK2 and DYRK1A suggested a novel mechanism for Wnt pathway inhibition, enhancing chondrogenesis, chondrocyte function, and anti-inflammation. Lorecivivint shows potential to modify structure and improve symptoms of knee OA.
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关键词
Lorecivivint,SM04690,Osteoarthritis,Wnt pathway,CLK2,DYRK1A,Chondrocyte
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