A PILOT TRIAL TO EVALUATE A HIGH-RESOLUTION, NON-INVASIVE URODYNAMIC STUDY TO MONITOR ELECTRICAL ACTIVITY OF THE HUMAN BLADDER

You have accessJournal of UrologyUrodynamics/Lower Urinary Tract Dysfunction/Female Pelvic Medicine: Neurogenic Voiding Dysfunction (MP07)1 Apr 2019MP07-02 A PILOT TRIAL TO EVALUATE A HIGH-RESOLUTION, NON-INVASIVE URODYNAMIC STUDY TO MONITOR ELECTRICAL ACTIVITY OF THE HUMAN BLADDER Sanghee Lee*, Hoang-Kim Le, Todd Coleman, Tris Mendoza, Thomas DiPina, George Chiang, Gladys Ornelas, Christina Jamieson, and Yahir Santiago-Lastra Sanghee Lee*Sanghee Lee* More articles by this author , Hoang-Kim LeHoang-Kim Le More articles by this author , Todd ColemanTodd Coleman More articles by this author , Tris MendozaTris Mendoza More articles by this author , Thomas DiPinaThomas DiPina More articles by this author , George ChiangGeorge Chiang More articles by this author , Gladys OrnelasGladys Ornelas More articles by this author , Christina JamiesonChristina Jamieson More articles by this author , and Yahir Santiago-LastraYahir Santiago-Lastra More articles by this author View All Author Informationhttps://doi.org/10.1097/01.JU.0000555086.77897.f6AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVES: Urodynamic studies are utilized in evaluating neurogenic bladder (NGB) and refractory overactive bladder (OAB), but are invasive and can cause significant bother to the patient. In addition, insertion of urethral catheters for vesical pressure monitoring and back-filling has a potential risk of urinary tract infection and its associated morbidity. In this pilot study, we combined the expertise of bioengineers, translational scientists and urologists to determine the feasibility and sensitivity of a novel non-invasive UDS (NI-UDS) system for dynamic bladder physiology assessment in healthy volunteers. METHODS: Cutaneous myoelectric recordings of the urinary bladder were measured from ten healthy subjects consisting of seven females (mean age 37.17±5.02 years) and three males (mean age 30.33±0.88 years) using NI-UDS. NI-UDS is performed with an array of eight surface electrodes (Ambu Blue Sensor-N) placed on the suprapubic region and left flank (ground) after reporting a full bladder. Data is recorded in three phases: (1) 5 mins 30 secs storage phase, (2) voluntary voiding, and (3) 5 minutes post-void phase. Statistical signal processing is performed with Python to determine spatial and temporal patterns in the three phases associated with wave propagation. Features include wave speed and whether or not a sustained wave is present at any point in time. RESULTS: Average percentages of sustained wave in the bladder of female subjects during storage, voiding and post-void phases were 0.71±0.05, 0.74±0.06 and 0.73±0.05, respectively. Interestingly, male subjects had lower average percentages of sustained wave compared to females (0.66±0.03, 0.68±0.03 and 0.67+0.03 for storage/filling phase, voluntary voiding and post-voiding phase, respectively). We also determined histograms of wave speed ranging 0-2, 2-4, 4-6, 6-8 and 8-9.5 mm/s. Strikingly, all subjects revealed lowest wave speeds during voluntary voiding, suggesting quiescent electrical activity in the bladder during this phase. CONCLUSIONS: Preliminary studies show that NI UDS is sensitive to determine physiological changes in gender-specific and voiding phase-specific manners. Furthermore, intrasubject consistency supports that NI UDS has potential in evaluating bladder dynamics in a non-invasive manner. Source of Funding: This study is supported by Adult and Pediatric Urology of University of California San Diego (UCSD) and San Diego Spina Bifida Association. La Jolla, CA© 2019 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 201Issue Supplement 4April 2019Page: e90-e90 Advertisement Copyright & Permissions© 2019 by American Urological Association Education and Research, Inc.MetricsAuthor Information Sanghee Lee* More articles by this author Hoang-Kim Le More articles by this author Todd Coleman More articles by this author Tris Mendoza More articles by this author Thomas DiPina More articles by this author George Chiang More articles by this author Gladys Ornelas More articles by this author Christina Jamieson More articles by this author Yahir Santiago-Lastra More articles by this author Expand All Advertisement PDF downloadLoading ...