Preclinical Evaluation of Endothelial Dysfunction by Peripheral Artery Tonometry and Its Correlations with Untargeted Metabolomic Profiles in NAFLD

Background: NAFLD has become one the most frequent liver disease in western countries. It is associated with Metabolic Syndrome, insulin resistance and diabetes. As well as the abovementioned conditions, it represents, a cardiovascular risk factor. Some evidences have demonstrated that Endothelial Dysfunction (ED),the pathophysiological basis of Cardiovascular Diseases (CVD),is present also in a part of NAFLD pts. ED can be evaluated in its “preclinical” status by performing vascular reactivity studies,such as Peripheral Artery Tonometry (PAT). However, not all NAFLD patients have a clinically demonstrable ED or a higher CVD risk. Untargeted Metabolomics is a novel and powerful method to discover biomarkers and give insights on diseases pathophysiology.