AB1000 Association of serum uric acid level with bone mineral density and osteoporosis in postmenopausal women with rheumatoid arthritis

Background Previous studies have reported that higher serum uric acid (SUA) levels are associated with higher bone mineral density (BMD) in men and postmenopausal women, and lower risk of fragility fracture in men. However, whether this association is also present in patients with rheumatoid arthritis (RA) has not yet been investigated. Objectives To examine the association of SUA levels with BMD and osteoporosis in postmenopausal women with RA. Methods We retrospectively evaluated 447 postmenopausal female RA patients (mean age 61.1 years) who underwent measurement of L1–4, femoral neck, and total hip BMD using dual energy X-ray absorptiometry, in addition to SUA levels at a university rheumatology centre in South Korea between 2004 and 2017. Osteoporosis was defined as a T-score of ≤−2.5 according to the World Health Organisation classification. Results The median (interquartile range) SUV level was 4 (3.3–4.8) mg/dL. The mean (±SD) L1–4, femoral neck, and total hip BMD were 0.93±0.16 g/cm2, 0.75±0.12 g/cm2, and 0.81±0.12 g/cm2, respectively, and the frequencies of osteoporosis in the spine, hip, and either site were 25.6%, 15.9%, and 32.5%, respectively. SUA levels were positively correlated with L1–4 (ρ=0.102, p=0.032), femoral neck (ρ=0.123, p=0.01), and total hip BMD values (ρ=0.146, p=0.002) and body mass index (ρ=0.231, p Conclusions Higher SUA levels were associated with a reduced risk of low BMD and osteoporosis at hip in postmenopausal women with RA, but no significant association between SUA levels and lumbar spine BMD was found. Our data suggests that uric acid may act as a protective factor against hip bone loss in RA patients. Disclosure of Interest None declared