Loquat-Inspired Janus Drug Delivery System for Flexible and Robust Tumor Targeting Therapy

With the inspiration of a fruit called Loquat, here we developed a similar shaped Janus carrier. This peculiar gold rod-partial exposed structure not only significantly increased the drug loading capability, but also improved its infrared response efficiency. A better effect of drug-photothermal treatment thus could be realized. With the aid of an external 3D printed drug guiding device, this carrier could accurately reach different affected area. The subsequent infrared triggered multiple tumor therapy thus could be conducted in the designatedlocation. The corresponding experimental results demonstrated the reliability, flexibility and biocompatibility of the proposed drug delivery system for two different tumor targeting treatments.