Oxidative β-Halogenation of Alcohols: A Concise and Diastereoselective Approach to Halohydrins
SYNLETT(2019)
摘要
beta-Halohydrins bearing transformable halo- and hydroxyl groups, are easily converted into various valuable blocks in organic and pharmaceutical synthesis. A diastereoselective -halogenation of benzylic alcohols was achieved under simple and low-cost conditions, which provided a direct synthesis of -halohydrins. The simple reaction conditions, easily available reagents, high diastereoselectivities, and additional oxidant-free make this reaction very attractive and practical.
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关键词
halogenation,alcohols,dimethyl sulfoxide,halohydrins,oxidation
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