An improved methodology for the synthesis of 1α,25-dihydroxy-20-epi-vitamin D3 (MC 1288) and Gemini analog Ro-438-3582
Organic chemistry frontiers(2017)
摘要
Control over the C-20 stereochemistry allows a versatile method to introduce novel side-chains into the vitamin D scaffold. Using our building blocks containing stereodefined stereochemistry at C-20 we demonstrated that we could improve the current synthesis of calcitriol analogs with potentially interesting biological properties.
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关键词
Vitamin D
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