TRAIL facilitates cytokine expression and macrophage migration during hypoxia/reoxygenation via ER stress-dependent NF-κB pathway

•TRAIL facilitated macrophage inflammatory factors production macrophage migration after hypoxia and reperfusion.•Production of macrophage cytokines induced by TRAIL dependent on activation of NF-κB and ER stress pathway.•ER stress signaling pathway contributed to the activation of the NF-κB signaling pathway.